Glycerol–Silicone Elastomers as Active Matrices with Controllable Release Profiles
نویسندگان
چکیده
منابع مشابه
Properties and active substance release kinetics from gelatin-alginate matrices.
The aim of the study was to evaluate the effect of composition and technological processing on pharmaceutical availability of active substance as well as on the properties of porous gelatin-alginate matrices. The active substance carrier included glycerol or peanut oil apart from gelatin and sodium alginate, and some matrices were additionally modified with calcium lactate. The obtained matrice...
متن کاملInfluence of Formulation Parameters on the Release of Diclofenace Sodium from Matrices with Manufacturing Formulation Ingredients
Effects of formulation parameters on the fractional release profile of diclofenac sodium from matrices having the manufacturing formulation ingredients are studied. As a content of cetyl alcohol (rate controlling agent) in the matrix increases, the fractional release decreases. The fractional release increases either by increasing sucrose content outside the granule or by decreasing sucrose...
متن کاملEffect of Formulation Variables on Phenobarbital Release from HPMC Matrices
Controlled release swellable tablets of phenobarbital were prepared by a simple direct compression process using hydroxypropyl methylcellulose (HPMC) as the matrix former. The effects of the viscosity grades of HPMC and HPMC/lactose ratio and ethylcellulose (EC)/sodium carboxymethylcellulose (NaCMC) and their concentrations on the release behavior of phenobarbital from HPMC matrices wer...
متن کاملOrdered mesoporous silicates as matrices for controlled release of drugs.
Interest in and thereby also development of ordered mesoporous silicates as drug delivery devices have grown immensely over the past few years. On hand selected cases from the literature, the power of such systems as delivery devices has been established. Specifically, it is shown how it is possible to enhance the release kinetics of poorly soluble drugs by embedding them in mesoporous silicate...
متن کاملActive Peptide-Conjugated Chitosan Matrices as an Artificial Basement Membrane
The basement membrane, a thin extracellular matrix, plays a critical role in tissue development and repair. Laminins are the major component of basement membrane and have diverse biological activities. We have identified various cell-adhesive peptides from laminins and their specific cell surface receptors. Polysaccharides, including chitosan, have been used as scaffolds, which regulate cellula...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Langmuir
سال: 2018
ISSN: 0743-7463,1520-5827
DOI: 10.1021/acs.langmuir.8b02039